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RIP3 (Phospho- Ser316 ) Antibody12840

  Catalog No. Package Size Price
12840-1 50ul $189.00
12840-2 100ul $279.00

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  • Product Name RIP3 (Phospho- Ser316 ) Antibody
  • Brief Description Rabbit Polyclonal
  • Host Species Rabbit
  • Clonality Polyclonal
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity Phospho-RIP3 ( S316 ) Antibody detects endogenous levels of RIP3 only when phosphorylated at S316
  • Immunogen Type Peptide-KLH
  • Immunogen Description A synthesized peptide derived from human RIP3 (Phospho- Ser316 )
  • Alternative Names Receptor interacting protein 3 antibody Receptor interacting serine threonine kinase 3 antibody Receptor interacting serine threonine protein kinase 3 antibody Receptor-interacting protein 3 antibody Receptor-interacting serine threonine-protein kinase 3 antibody RIP 3 antibody RIP like protein kinase 3 antibody RIP-3 antibody RIP-like protein kinase 3 antibody RIPK 3 antibody RIPK3 antibody RIPK3_HUMAN antibody
  • Accession No. Swiss-Prot#:Q9QZL0
    NCBI Gene ID56532
  • Calculated MW 46-62
  • Concentration 1.0mg mL
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

WB dilution:1:1000

  • RIP3 (Phospho- Ser316 ) Antibody - Absci

    Western blot analysis RIP3 (Phospho- Ser316 ) using EGF treated MCF7 whole cell lysates

Product Description
The receptor-interacting protein (RIP) family of serine-threonine kinases (RIP, RIP2, RIP3, and RIP4) are important regulators of cellular stress that trigger pro-survival and inflammatory responses through the activation of NF-��B, as well as pro-apoptotic pathways (1). In addition to the kinase domain, RIP contains a death domain responsible for interaction with the death domain receptor Fas and recruitment to TNF-R1 through interaction with TRADD (2,3). RIP-deficient cells show a failure in TNF-mediated NF-��B activation, making the cells more sensitive to apoptosis (4,5). RIP also interacts with TNF-receptor-associated factors (TRAFs) and can recruit IKKs to the TNF-R1 signaling complex via interaction with NEMO, leading to I��B phosphorylation and degradation (6,7). Overexpression of RIP induces both NF-��B activation and apoptosis (2,3). Caspase-8-dependent cleavage of the RIP death domain can trigger the apoptotic activity of RIP (8)
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    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  

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