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Recombinant Human Pro-neuregulin-3, membrane-bound isoform(NRG3),partialAP73811

Catalog No.	Package Size	Price
AP73811-1	10ug	$105.00
AP73811-2	50ug	$260.00
AP73811-3	100ug	$454.00
AP73811-4	200ug	$735.00
AP73811-5	500ug	$1240.00
AP73811-6	1mg	$1980.00

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Availability: The lead time is currently 7-30 days.

Description

Product Name Recombinant Human Pro-neuregulin-3, membrane-bound isoform(NRG3),partial
Brief Description Recombinant Protein
Host Species E.coli
Target Name NRG3
Alternative Names Pro-NRG3
Accession No. Uniprot ID: P56975
Target Species Hu
SDS-PAGE MW 53.76kDa
Target Length Extracellular Domain,1-360aa
Tag Info N-terminal 6xHis-SUMO-tagged
Target Sequence MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQ
Formulation Tris-based buffer,50% glycerol
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20˚C/-80˚C. The shelf life of lyophilized form is 12 months at -20˚C/-80˚C.

Application Details

Greater than 90% as determined by SDS-PAGE.

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Background

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes

Regerences

"Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4."Zhang D., Sliwkowski M.X., Mark M., Frantz G., Akita R., Sun Y., Hillan K., Crowley C., Brush J., Godowski P.J.Proc. Natl. Acad. Sci. U.S.A. 94:9562-9567(1997)

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