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Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx(vpx)AP73804

Catalog No.	Package Size	Price
AP73804-1	10ug	$105.00
AP73804-2	50ug	$260.00
AP73804-3	100ug	$454.00
AP73804-4	200ug	$735.00
AP73804-5	500ug	$1240.00
AP73804-6	1mg	$1980.00

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Availability: The lead time is currently 7-30 days.

Description

Product Name Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx(vpx)
Brief Description Recombinant Protein
Host Species E.coli
Target Name vpx
Alternative Names Viral protein X X ORF protein
Accession No. Uniprot ID: P06939
Target Species Human immunodeficiency virus type 2 subtype A (isolate ROD)
SDS-PAGE MW 28.81kDa
Target Length Full Length,1-112aa
Tag Info N-terminal 6xHis-SUMO-tagged
Target Sequence MTDPRETVPPGNSGEETIGEAFAWLNRTVEAINREAVNHLPRELIFQVWQRSWRYWHDEQGMSESYTKYRYLCIIQKAVYMHVRKGCTCLGRGHGPGGWRPGPPPPPPPGLV
Formulation Tris-based buffer,50% glycerol
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20˚C/-80˚C. The shelf life of lyophilized form is 12 months at -20˚C/-80˚C.

Application Details

Greater than 90% as determined by SDS-PAGE.

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Background

Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).

Regerences

"Identification of the nuclear localization signal of human immunodeficiency virus type 2 Vpx."Belshan M., Ratner L.Virology 311:7-15(2003)

Published Papers

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