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Recombinant Human Integrin alpha-2(ITGA2) ,partialAP73802

Catalog No.	Package Size	Price
AP73802-1	10ug	$105.00
AP73802-2	50ug	$260.00
AP73802-3	100ug	$454.00
AP73802-4	200ug	$735.00
AP73802-5	500ug	$1240.00
AP73802-6	1mg	$1980.00

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Availability: The lead time is currently 7-30 days.

Description

Product Name Recombinant Human Integrin alpha-2(ITGA2) ,partial
Brief Description Recombinant Protein
Host Species E.coli
Target Name ITGA2
Alternative Names CD49 antigen-like family member B Collagen receptor Platelet membrane glycoprotein Ia Short name: GPIa VLA-2 subunit alpha CD_antigen: CD49b
Accession No. Uniprot ID: P17301
Target Species Hu
SDS-PAGE MW 35.63kDa
Target Length Partial,188-365aa
Tag Info N-terminal 6xHis-SUMO-tagged
Target Sequence WDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIE
Formulation Tris-based buffer,50% glycerol
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20˚C/-80˚C. The shelf life of lyophilized form is 12 months at -20˚C/-80˚C.

Application Details

Greater than 90% as determined by SDS-PAGE.

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Background

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized Extracellular domain matrix.

Regerences

"The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain."Takada Y., Hemler M.E.J. Cell Biol. 109:397-407(1989)

Published Papers

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