HTR2A Antibody

Description

Product Name HTR2A Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antigen affinity purification.
Applications WB IHC Elisa
Species Reactivity Hu Rt Hu
Specificity The antibody detects endogenous levels of total HTR2A protein.
Immunogen Description Synthetic peptide of human HTR2A
Target Name HTR2A
Alternative Names HTR2; 5-HT2A
Accession No. Swiss-Prot#: P28223
Gene ID: 3356
Calculated MW 53kd
Concentration 0.9mg/ml
Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage Store at -20˚C

Application Details

Western blotting: 1:1000-1:5000

Immunohistochemistry: 1:20-1:100

ELISA dilution: 1: 5000-1:10000

Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: Human fetal brain tissue lysate Primary antibody: D262769(HTR2A Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 30 seconds Gel: 8%SDS-PAGE
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using D262769(HTR2A Antibody) at dilution 1/20, on the right is treated with synthetic peptide.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using D262769(HTR2A Antibody) at dilution 1/20, on the right is treated with synthetic peptide.

Background

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene.

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