BMF Antibody

Description

Product Name BMF Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antigen affinity purification.
Applications WB IHC
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous levels of total BMF protein.
Immunogen Description Synthetic peptide of human BMF
Target Name BMF
Alternative Names Bcl-2-modifying factor; Bcl2 modifying factor; BMF; FLJ00065
Accession No. Swiss-Prot#: Q96LC9
Gene ID: 90427
Calculated MW 21kd
Concentration 0.8mg/ml
Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage Store at -20˚C

Application Details

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100

Images

Gel: 12%SDS-PAGE
Lysate: 40 μg
Lane 1-4: Hepg2
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #43281 at dilution 1/20,

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis.

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