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Recombinant Human E3 ubiquitin-protein ligase MYLIPAP73111

Catalog No.	Package Size	Price
AP73111-1	50ug	$260.00
AP73111-2	200ug	$735.00
AP73111-3	500ug	$1240.00
AP73111-4	1mg	$1975.00

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Availability: The lead time is currently 7-30 days.

Description

Product Name Recombinant Human E3 ubiquitin-protein ligase MYLIP
Brief Description Recombinant Protein
Host Species Yeast
Target Name MYLIP
Alternative Names Inducible degrader of the LDL-receptor ;IdolMyosin regulatory light chain interacting protein ;MIR
Accession No. Uniprot ID: Q8WY64
Target Species HUMAN
Calculated MW 51.9kD
Target Length Full length, 1-445aa
Tag Info His-tag
Target Sequence MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI
Formulation 20mM Tris-HCl based buffer,pH8.0
Storage Store at -20˚C, for extended storage, conserve at -20˚C or -80˚C. Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.

Application Details

Purity: Greater than 90% as determined by SDS-PAGE.

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Background

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

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