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Recombinant Homo sapiens Twinkle protein, mitochondrialAP73105
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Description
Product NameRecombinant Homo sapiens Twinkle protein, mitochondrial
Brief DescriptionRecombinant Protein
Host SpeciesYeast
Target NamePEO1
Alternative NamesProgressive external ophthalmoplegia 1 protein;T7 gp4-like protein with intramitochondrial nucleoid localization;T7-like mitochondrial DNA helicase
StorageStore at -20˚C, for extended storage, conserve at -20˚C or -80˚C. Repeated freezing and thawing is not recommended. Store working aliquots at 4˚C for up to one week.
Application Details
Purity: Greater than 90% as determined by SDS-PAGE.
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Background
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as tplate to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.