CXCL12 Antibody

Description

Product Name CXCL12 Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antigen affinity purification.
Applications IHC
Species Reactivity Hu
Specificity The antibody detects endogenous levels of total CXCL12 protein.
Immunogen Type Peptide
Immunogen Description Synthetic peptide corresponding to a region derived from internal residues of human chemokine (C-X-C motif) ligand 12
Target Name CXCL12
Alternative Names IRH; PBSF; SDF1; TLSF; SDF1A; SDF1B; TPAR1; SCYB12
Accession No. Swiss-Prot#: P48061
NCBI Gene ID: 6387
Gene Accssion: NP_000600
Concentration 0.7mg/ml
Formulation Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage Store at -20˚C

Application Details

Immunohistochemistry: 1:25-1:100

Images

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using #37236 at dilution 1/20.
Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue using #37236 at dilution 1/20.

Background

This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

Published Papers

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