ABCG2(CD338) Antibody

Description

Product Name ABCG2(CD338) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Human
Specificity The antibody detects endogenous level of total ABCG2(CD338) protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.160~164( R-I-N-R-V) derived from Human ABCG2(CD338).
Target Name ABCG2(CD338)
Alternative Names BMDP; MRX; ABC15; ABCP; BCRP1
Accession No. Swiss-Prot: Q9UNQ0
NCBI Protein: NP_004818.2
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 65-80kd
Western blotting: 1:500

Images

Western blot analysis of extract from HL-60 cells using ABCG2(CD338) Antibody #AB21476

Background

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Henriksen U., Gether U., Litman T.J. Cell Sci. 118:1417-1426(2005) Wakabayashi K., Nakagawa H., Tamura A., Koshiba S., Hoshijima K., Komada M., Ishikawa T. J. Biol. Chem. 282:27841-27846(2007)

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