PHLDA3 Antibody

Description

Product Name PHLDA3 Antibody
Host Species Rabbit
Clonality Polyclonal
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Applications IHC
Species Reactivity Hu
Specificity The antibody detects endogenous levels of total PHLDA3 protein.
Immunogen Type Peptide
Immunogen Description Synthesized peptide derived from internal of human PHLDA3.
Target Name PHLDA3
Alternative Names Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; PHLDA3; TIH1;
Accession No. Swiss-Prot: Q9Y5J5
NCBI Gene ID: 23612
SDS-PAGE MW 15kd
Concentration 1.0mg/ml
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C

Application Details

Immunohistochemistry: 1:50~1:100

Images

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PHLDA3 antibody #AB34295.

Background

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

Frank D., Mamm. Genome 10:1150-1159(1999).
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Published Papers

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