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Heme Oxygenase 1(HO-1) AntibodyAB48715

  Catalog No. Package Size Price
48715-1 50ul $260.00
48715-2 100ul $390.00

Quantity:  Total:   
 

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Description
  • Product Name Heme Oxygenase 1(HO-1) Antibody
  • Clone No. SP08-07
  • Purification ProA affinity purified
  • Applications WB, IHC, IP, FC
  • Species Reactivity Hu, Ms
  • Immunogen Description recombinant protein
  • Alternative Names 32 kD antibody
    bK286B10 antibody
    D8Wsu38e antibody
    heat shock protein 32 kD antibody
    heat shock protein 32kD antibody
    Heat shock protein antibody
    Heme oxygenase (decycling) 1 antibody
    Heme oxygenase 1 antibody
    Hemox antibody
    HMOX 1 antibody
    Hmox antibody
    Hmox1 antibody
    HMOX1_HUMAN antibody
    HO 1 antibody
    HO antibody
    HO-1 antibody
    HO1 antibody
    Hsp32 antibody
  • Accession No. Swiss-Prot#:P09601
  • Calculated MW 33 kDa
  • Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Storage Store at -20˚C
Application Details

 WB: 1:1,000 
IHC:1:50-1:200 


FC: 1:50-1:100

Images
  • Heme Oxygenase 1(HO-1) Antibody - Absci


  • Heme Oxygenase 1(HO-1) Antibody - Absci


  • Heme Oxygenase 1(HO-1) Antibody - Absci


  • Heme Oxygenase 1(HO-1) Antibody - Absci


Background

 Heme oxygenases are microsomal enzymes that cleave heme to produce the antioxidant biliverdin, inorganic iron and carbon monoxide (CO). The activity of Heme Oxygenase 1 (HO-1), also designated HSP 32, is highly inducible in response to numerous stimuli, including heme, heavy metals, hormones and oxidative stress. Heme Oxygenase 2, in contrast, appears to be constituitively expressed in mammalian tissues. Heme Oxygenase 2 is involved in the production of carbon monoxide (CO) in brain, where CO is thought to act as a neurotransmitter. The CO signaling system closely parallels the signaling pathway involving nitric oxide, and regulation of the two systems is closely linked. Heme Oxygenase 3 is found in the spleen, liver, thymus, prostate, heart, kidney, brain and testis. A poor heme catalyst, Heme Oxygenase 3 has two heme regulatory motifs that may be involved in heme binding.

Regerences

 1. He C et al. Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration. Proc Natl Acad Sci U S A 111:14806-11 (2014).
2. Maruyama A et al. Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding. Nucleic Acids Res 42:13599-614 (2014).

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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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