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GRB10 (Phospho-Ser503) Antibody12850

  Catalog No. Package Size Price
12850-1 50ul $189.00
12850-2 100ul $279.00

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Description
  • Product Name GRB10 (Phospho-Ser503) Antibody
  • Brief Description Rabbit Polyclonal
  • Host Species Rabbit
  • Clonality Polyclonal
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity Phospho-GRB10 (S503) Antibody detects endogenous levels of GRB10 only when phosphorylated at S503
  • Immunogen Type Peptide-KLH
  • Immunogen Description A synthesized peptide derived from human GRB10 (Phospho-Ser503)
  • Alternative Names grb 10 antibody GRB IR antibody grb-10 antibody GRB10 adapter protein antibody GRB10 adaptor protein antibody GRB10 antibody GRB10_HUMAN antibody GRBIR antibody Growth factor receptor bound protein 10 antibody Growth factor receptor-bound protein 10 antibody Insulin receptor binding protein antibody Insulin receptor binding protein GRB IR antibody Insulin receptor-binding protein Grb-IR antibody IRBP antibody KIAA0207 antibody Maternally expressed gene 1 antibody MEG1 antibody RSS antibody
  • Accession No. Swiss-Prot#:Q13322
    NCBI Gene ID2887
  • Calculated MW 76
  • Concentration 1.0mg mL
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

WB dilution:1:1000

Images
  • GRB10 (Phospho-Ser503) Antibody - Absci

    Western blot analysis GRB10 (Phospho-Ser503) using EGF treated HeLa whole cell lysates

Product Description
Recently GRB10 was shown to be a direct substrate of mTORC1 (5). It is phosphorylated by mTORC1 at Ser150, Ser428, and Ser476 upon insulin stimulation (5).The GRB7 family of adaptor proteins consist of GRB7, GRB10 and GRB14, which all contain an amino-terminal proline-rich SH3 binding domain, followed by PH, PBS, and SH2 domains. Each member of the family has several splice variants (1). It has been reported that GRB10 interacts with many receptor tyrosine kinases (RTKs) as well as downstream signal molecules including Raf, Akt, and Nedd4 (1,2). Although it was originally thought that GRB10 is exclusively phosphorylated at serine residues (3), Src kinase family members have been shown to phosphorylate GRB10 at Tyr67 (4).
    Please let us know if you have published research using #12850 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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