Predicted MW: 155kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
Zhang W, et al. (2005) J Biol Chem. 280(19): 19036-19044.
Fujii K, et al. (2004) Oncogene. 23(29):5099-5104.
Goldman EH, et al. (2004) J Biol Chem 2004 Mar 12; 279(11): 10442-10449.
Zhang L, et al. (1999) Proc Natl Acad Sci U S A. 96(15): 8511-8515.
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